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Total posts by Louise A. Griffiths: 2

publication · 1 month ago
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
by Niall M. Hamilton, Emma E. Fairweather, Nicola S. Hamilton, James R. Hitchin, Dominic I. James, Allan M. Jordan, Helen F. Small, Ian D. Waddell, Donald J. Ogilvie, Alison E. McGonagle, Daniel P. Mould, Kate M. Smith, Bohdan Waszkowycz, Louise A. Griffiths, Colin P. Hutton, Stuart Jones, Alexandra I. J. Stowell, Ben Acton, Clifford D. Jones, Julie A. Tucker (The University of Manchester)
publication · 11 months ago
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib
by Emma E. Fairweather, Nicola S. Hamilton, James R. Hitchin, Dominic I. James, Allan M. Jordan, Ian D. Waddell, Donald J. Ogilvie, Alison E. McGonagle, Kate M. Smith, Bohdan Waszkowycz, Louise A. Griffiths, Colin P. Hutton, Stuart Jones, Paul Kelly, Helen Small, Alexandra I. J. Stowell, Julie Tucker (AstraZeneca, University of Manchester)