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Total posts by Nicola S. Hamilton: 4

publication · 1 month ago
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
by Niall M. Hamilton, Emma E. Fairweather, Nicola S. Hamilton, James R. Hitchin, Dominic I. James, Allan M. Jordan, Helen F. Small, Ian D. Waddell, Donald J. Ogilvie, Alison E. McGonagle, Daniel P. Mould, Kate M. Smith, Bohdan Waszkowycz, Louise A. Griffiths, Colin P. Hutton, Stuart Jones, Alexandra I. J. Stowell, Ben Acton, Clifford D. Jones, Julie A. Tucker (The University of Manchester)
publication · 11 months ago
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib
by Emma E. Fairweather, Nicola S. Hamilton, James R. Hitchin, Dominic I. James, Allan M. Jordan, Ian D. Waddell, Donald J. Ogilvie, Alison E. McGonagle, Kate M. Smith, Bohdan Waszkowycz, Louise A. Griffiths, Colin P. Hutton, Stuart Jones, Paul Kelly, Helen Small, Alexandra I. J. Stowell, Julie Tucker (AstraZeneca, University of Manchester)
publication · 5 years ago
Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II
by Niall M. Hamilton, Nicola S. Hamilton, James R. Hitchin, Allan M. Jordan, Helen F. Small, Graeme J. Thomson, Ian D. Waddell, Donald J. Ogilvie, Ali Raoof, Paul Depledge, Gemma V. Hopkins, Laura A. Maguire, Alison E. McGonagle, Daniel P. Mould, Mathew Rushbrooke, Kate M. Smith, Fabrice Turlais, Bohdan Waszkowycz, Amanda J. Watson (University of Manchester, Wolfson Institute for Biomedical Research)
publication · 6 years ago
Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase
by Niall M. Hamilton, Martin Dawson, Emma E. Fairweather, Nicola S. Hamilton, James R. Hitchin, Dominic I. James, Stuart D. Jones, Allan M. Jordan, Amanda J. Lyons, Helen F. Small, Graeme J. Thomson, Ian D. Waddell, Donald J. Ogilvie (Paterson Institute for Cancer Research)