This presentation introduces techniques to manage small molecule data from your desktop, utilizing ChemAxon's tool Instant JChem and managing your data with MS Excel extension JChem for Office. JChem for Office integrates chemical structure handling, data analyzing, visualizing and reporting capabilities within the Microsoft Office environment. Structures can be edited and also copy/pasted throughout Excel spreadsheets, Word documents, PowerPoint slides and even Outlook e-mails. The JChem add-on equips your Excel with robust chemistry handling. It provides ultra fast loading or scrolling throughout virtually thousands of structure rows. Structure based calculations, R-group decomposition, library enumeration and SAR-table generation belong to the more advanced functionalities that JChem for Office can offer.