ChemAxon - Software Solutions and Services for Chemistry & Biology

Total posts by University of Cambridge: 14

publication · 3 months ago

Orthologue chemical space and its influence on target prediction

by Andreas Bender, Fredrik Svensson, Lewis H. Mervin, Avid M. Afzal, Ola Engkvist, Krishna C. Bulusu, Leen Kalash, Mike A. Firth, Ian Barrett (AstraZeneca, University of Cambridge, AstraZeneca R&D Gothenburg)

publication · 7 months ago

MANORAA (Mapping Analogous Nuclei Onto Residue And Affinity) for identifying protein-ligand fragment interaction, pathways and SNPs

by Duangrudee Tanramluk, Lalita Narupiyakul, Ruj Akavipat, Sungsam Gong, Varodom Charoensawan (Mahidol University, University of Cambridge)

publication · 7 months ago

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

publication · 7 months ago

Target prediction utilising negative bioactivity data covering large chemical space

by Andreas Bender, Richard Lewis, Lewis H. Mervin, Avid M. Afzal, Georgios Drakakis, Ola Engkvist (University of Cambridge)

publication · 7 months ago

Bespoke affinity ligands for the purification of therapeutic proteins

by Graziella El Khoury, Christopher R. Lowe, Basmah Khogeer, Chen Chen, Kheng T Ng, Shaleem I Jacob (University of Cambridge)

publication · 7 months ago

Bespoke affinity ligands for the purification of therapeutic proteins

by Graziella El Khoury, Christopher R. Lowe, Basmah Khogeer, Chen Chen, Kheng T Ng, Shaleem I Jacob (University of Cambridge)

publication · 7 months ago

Synergy Maps: exploring compound combinations using network-based visualization

by Andreas Bender, Rajarshi Guha, Richard Lewis, Tamás Korcsmaros (University of Cambridge, National Center for Advancing Translational Sciences, TGAC, The Genome Analysis Centre Norwich Research Park)

publication · 2 years ago

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins

by Priyanka Joshi, Sean Chia, Johnny Habchi, Tuomas Knowles, Christopher Dobson, Michele Vendruscolo (University of Cambridge)

publication · 5 years ago

A biomimetic Protein G affinity adsorbent: an Ugi ligand for immunoglobulins and Fab fragments based on the third IgG-binding domain of Protein G

by Graziella El Khoury, Christopher R. Lowe (University of Cambridge)

publication · 6 years ago

Using a Fragment-Based Approach To Target Protein- Protein Interactions

by Duncan E. Scott, Matthias T. Ehebauer, Tara Pukala, May Marsh, Tom L. Blundell, Ashok R. Venkitaraman, Chris Abell, Marko Hyvonen (University of Cambridge, University of Adelaide)

publication · 6 years ago

Development and Comparison of hERG Blocker Classifiers: Assessment on Different Datasets Yields Markedly Different Results

by Robert C. Glen, John B.O. Mitchell, Richard L. Marchese Robinson (University of St Andrews, University of Cambridge)

publication · 7 years ago

chemicalize.org

by Matthew Swain (University of Cambridge)

publication · 7 years ago

Chemical Name to Structure: OPSIN, an Open Source Solution

by Robert C. Glen, Daniel M. Lowe, Peter T. Corbett, Peter Murray-Rust (University of Cambridge)

publication · 7 years ago

Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases

by Florian Nigsch, John B.O. Mitchell (University of Cambridge)