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Total posts by University of Pittsburgh: 9

publication · 9 months ago
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b] thiadiazines, a new class of STAT3 pathway inhibitors
by Peter Wipf, Paul A. Johnston, Matthew G. LaPorte, Zhuzhu Wang, Raffaele Colombo, Atefeh Garzan, Vsevolod A. Peshkov, Mary Liang, Mark E. Schurdak, Malabika Sen, Daniel P. Camarco, Yun Hua, Netanya I. Pollock, John S. Laz, Jennifer R. Grandis, Donna M. Huryn (University of Pittsburgh, University of Virginia)
publication · 9 months ago
Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]- 1-(4-phenylpiperazin-1-yl)ethanone
by Peter Wipf, Khalid Z. Masoodi, Kurtis Eisermann, Zhenyu Yang, Javid A. Dar, Laura E. Pascal, Minh Nguyen, Katherine O’Malley, Erica Parrinello, Firuz G. Feturi, Alex N. Kenefake, Joel B. Nelson, Paul A. Johnston, Zhou Wang (University of Pittsburgh, Kent State University, University of Pittsburgh School of Medicine, Central South University, King Saud University)
publication · 1 year ago
Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5
by Xiang-Qun Xie, Yuemin Bian, Zhiwei Feng, Peng Yang (University of Pittsburgh)
publication · 5 years ago
Linear and Nonlinear Support Vector Machine for the Classification of Human 5-HT1A Ligand Functionality
by Peter Wipf, Lirong Wang, Xiang-Qun Xie, Chao Ma (University of Pittsburgh)
publication · 6 years ago
Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists
by Wei Wang, Alexander Dömling, David Koes, Kareem Khoury, Yijun Huang, Michal Bista, Grzegorz M. Popowicz, Siglinde Wolf, Tad A. Holak, Carlos J. Camacho (University of Pittsburgh, Max Planck Institute of Biochemistry)
publication · 7 years ago
Residue Preference Mapping of Ligand Fragments in the Protein Data Bank
by Peter Wipf, Lirong Wang, Zhaojun Xie, Xiang-Qun Xie (University of Pittsburgh)
publication · 8 years ago
Screening Multicomponent Reactions for X-Linked Inhibitor of Apoptosis-Baculoviral Inhibitor of Apoptosis Protein Repeats Domain Binder
by Alexander Dömling, Ilaria Monfardini, Jui-Wen Huang, Barbara Beck, Jason F. Cellitti, Maurizio Pellecchia (University of Pittsburgh)
publication · 8 years ago
Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones
by Jared T. Hammill, Aaron M. Virshup, David N. Beratan, Weitao Yang, Peter Wipf, Contreras-García Julia (University of Pittsburgh)
publication · 8 years ago
Efficient Synthesis Of Arrays Of Amino Acid Derived Ugi Products With Subsequent Amidation
by Wei Wang, Alexander Dömling (University of Pittsburgh)