A Robotic Chemistry System for the Discovery of Cancer-Specific Targeting Ligands

presentation · 8 years ago
by John Frangioni (Beth Israel Deaconess Medical Center, Harvard Medical School)
JChem Cartridge JChem Base

Improved cancer diagnostics and therapeutics will require targeting ligands with relatively high specificity for the surface of malignant cells compared to normal cells. However, the discovery of such tumor-specific ligands is extremely difficult. We are developing an integrated system, comprised of six robotic workstations, for the automated synthesis, screen, and identification of small molecules that bind with high affinity to the cancer cell surface. JChem, in conjunction with an Oracle database, is being used to manage the complex chemical information produced by such a system. This talk will describe this “work in progress” and demonstrate how the tools within JChem can be employed for high-throughput small molecule screens.