Rhea, an expert curated knowledgebase of biochemical reactions for enzyme annotation and genome-scale metabolic modeling

presentation · 2 years ago
by Anne Morgat, Dániel Szisz (ChemAxon, SIB Swiss Institute of Bioinformatics)

Rhea is an expert curated knowledgebase of over 10,000 biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. Rhea serves as a base for the SwissLipids knowledgebase for lipid biology and is a reference for many other knowledge resources and data repositories such as UniProt, from 2018), the metabolic modelling platform MetaNetX, and the metabolomics repository MetaboLights. In this talk we will describe how Marvin tools are used in Rhea and related projects as well as other recent developments including new data mining tools (such as our new beta SPARQL endpoint at the Swiss Institute of Bioinformatics.

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