Study Frequent High-throughput Screening Hits

presentation · 6 years ago
by Yingyao Zhou (Genomics Institute of the Novartis Research Foundation)
It has been noted that certain compounds frequently appear as hits in many high-throughput screening campaigns. The typical practice of removing frequent hits based on their empirical hit frequency carries the risk of removing compounds with desirable properties. We studied several important aspects of frequent hits, including their biological context, mechanisms, and chemical features; we then proposed an ABC frequent hit triage strategy. Details of this study can be found at J. Chem. Inf. Model. 2012, 52, 913−926. Download slides