Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB

publication · 8 years ago
by Kong Nguyen, Salahuddin Syed, Stephan Urwyler, Daniel Bertrand, Jean-Louis Reymond, Sonia Bertrand (University of Berne)
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The first virtual screening search through the entire chemical space of small organic ligands has identified promising ligands as inhibitors of the N-methyl-D-aspartic acid (NMDA) receptor glycine site. This receptor is an important drug target implicated in synaptic plasticity, neuronal development, learning, and memory. Inhibiting the NMDA receptor may help prevent neuronal cell death caused by glutamate excitotoxicity in acute and chronic neurodegenerative disorders.
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