Synthesis of novel halo-oxybispyridines, new building blocks in cholinergic medicinal chemistry

publication · 8 years ago
by Aurélien Lesnard, Sylvain Rault, Anne Sophie Voisin, Alexandre Bouillon, Jean Lancelot-Charles (UFR des Sciences Pharmaceutiques, BoroChem)
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This paper describes a method for the preparation of oxybispyridines bearing several halogens, which could be further transformed into other functional groups thus giving access to libraries with the bis-pyridyl ether moiety as the common structural feature of interest in cholinergic medicinal chemistry. Scope and limitation of the method are outlined.
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