The influence of pH on the G-quadruplex binding selectivity of perylene derivatives

publication · 10 years ago
by Wirote Tuntiwechapikul, Thanachai Taka, Mathilde Bethencourt, Luksana Makonkawkeyoon, T. Randall Lee (Chiang Mai University)
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Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity.
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