The influence of pH on the G-quadruplex binding selectivity of perylene derivatives

publication · 8 years ago
by Wirote Tuntiwechapikul, Thanachai Taka, Mathilde Bethencourt, Luksana Makonkawkeyoon, T. Randall Lee (Chiang Mai University)
Calculator Plugins (logP logD pKa etc...)
Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity.
Visit publication