The University of Minnesota Pathway Prediction System: multi-level prediction and visualization

publication · 9 years ago
by Lawrence P. Wackett, Lynda B. M. Ellis, Junfeng Gao (University of Minnesota)
The University of Minnesota Pathway Prediction System (UM-PPS) is a rule-based system that predicts microbial catabolism of organic compounds. Currently, its knowledge base contains 250 biotransformation rules and five types of metabolic logic entities. The original UM-PPS predicted up to two prediction levels at a time. Users had to choose a predicted product to continue the prediction. This approach provided a limited view of prediction results and heavily relied on manual intervention. The new UM-PPS produces a multi-level prediction within an acceptable time frame, and allows users to view prediction alternatives much more easily as a directed acyclic graph.
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