Three new asperentin derivatives from the algicolous fungus Aspergillus sp. F00785.

publication · 1 year ago
by Qian Tang, Kai Guo, Xiao-Yang Li, Xiu-Ying Zheng, Xiang-Jian Kong, Zhong-Hui Zheng, Qing-Yan Xu, Xianming Deng (Xiamen University)

Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5-9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of compound 9. Compound 4 exhibited highly potent inhibitory activity against crop pathogens, Colletotrichum gleosporioides Penz. and Colletotrichum gleosporioides (Penz.) Sacc.

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