The informatics team at the Genomics Institute of the Novartis Research Foundation (GNF) has been developing a comprehensive lead discovery database (LDDB) in order to support an aggressive drug discovery portfolio. The chemical structure searching capability of LDDB has been supported by the combination of Marvin and Daylight cartridge until 2004. However, we are migrating into an exclusive ChemAxon platform. This presentation intends to share with the user group our experience in using different vendor products, while focusing on the issues related to our cartridge migration process. Examples illustrating how ChemAxon tools are used in LDDB are also presented.