Use of Associated Chromatographic Techniques in Bio-Monitored Isolation of Bioactive Monoterpenoid Indole Alkaloids from Aspidosperma ramiflorum

publication · 6 years ago
by Talita Perez Cantuaria Chierrito, Ananda de Castro Cunha, Regina Aparecida Correia Gonçalves, Luzia Koike, Arildo José Braz de Oliveira (Universidade Estadual de Maringá, Universidade Estadual de Campinas)
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The genus Aspidosperma (Apocynaceae) have been commonly used in folk medicine as potential antimalarial agents; in the treatment of leishmaniasis; uterus and ovary inflammations; as a contraceptive; in diabetes; stomach disorders; against cancer; fever and rheumatism (Oliveira et al, 2009). It commonly grows in tropical America, extracted from trees ranging 2 to 60 m in height. It is found in a variety of habitats from the dry fields of south-central Brazil, Paraguay, and Argentina to the inundated river margins of the Amazon basin (Tanaka, 2006). The main constituents of the Aspidosperma genus are indole alkaloids, a class of substances with a wide range of pharmacological activities such as cholinesterase inhibitors, analgesic, anti-inflammatory, bactericidal, oestrogenic, stimulant and depressant of the central nervous system (CNS) (Zocoler et al, 2005).

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