Use of Associated Chromatographic Techniques in Bio-Monitored Isolation of Bioactive Monoterpenoid Indole Alkaloids from Aspidosperma ramiflorum

publication · 9 years ago
by Talita Perez Cantuaria Chierrito, Ananda de Castro Cunha, Regina Aparecida Correia Gonçalves, Luzia Koike, Arildo José Braz de Oliveira (Universidade Estadual de Maringá, Universidade Estadual de Campinas)

The genus Aspidosperma (Apocynaceae) have been commonly used in folk medicine as potential antimalarial agents; in the treatment of leishmaniasis; uterus and ovary inflammations; as a contraceptive; in diabetes; stomach disorders; against cancer; fever and rheumatism (Oliveira et al, 2009). It commonly grows in tropical America, extracted from trees ranging 2 to 60 m in height. It is found in a variety of habitats from the dry fields of south-central Brazil, Paraguay, and Argentina to the inundated river margins of the Amazon basin (Tanaka, 2006). The main constituents of the Aspidosperma genus are indole alkaloids, a class of substances with a wide range of pharmacological activities such as cholinesterase inhibitors, analgesic, anti-inflammatory, bactericidal, oestrogenic, stimulant and depressant of the central nervous system (CNS) (Zocoler et al, 2005).

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