Reaxys and Reaxys Medicinal Chemistry (RMC) is a first-class chemistry solution designed to support chemistry, pharma, environmental & material research. Its user-friendly and intuitive interface offers retrieval of a wide range of chemistry data which is stored & managed in a robust database. This is supported by a wide range of chemistry related search functionalities, including structure and reaction search, property search and NLP supported text search based on continuously updated and expanded taxonomies focused on chemistry and pharmacology disciplines. Reaxys and RMC’s end-to-end processing workflow embeds and employs ChemAxon’s technology in various stages and processes; from supporting manual excerption of factual data from full text publications (literature articles or patents), for chemical entity visualization, annotation and enumeration, and for advanced structure search and retrieval functionalities. ChemAxon’s technology also provides presentation of structures and molecules to the end-user on the Reaxys and RMC’s User Interface. The focus of the presentation will be on demonstration and usage of ChemAxon’s cheminformatics tools and applications in Reaxys and Reaxys Medicinal Chemistry.