Our new application has been born out of years of evolution on Marvin Live and a big expansion in 2019, related to hypothesis life-cycle management. We present key capabilities - such as an all new drawing experience, guided molecule design, virtual registration, kanban boards and a universal search engine. We take a thorough look at the various ways the cheminformatics landscape can be tied into Design Hub with the introduction of several classes of new plugins for databases searches (e.g. Enamine REAL) or ADMET property prediction (e.g. the all new ChemAxon hERG predictor). The presentation ends with a look at available cloud subscription plans.