Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging
Molecular probes that selectively highlight pancreatic cancer (PC) tissue have the potential to improve pancreatic ductal adenocarcinoma (PDAC) margin assessment through the selective highlighting of individual PC cells. Herein, we report a simple and unique family of systematically modified red and near-infrared fluorescent probes that exhibit a field-effect-derived redshift. Two of thirteen probes distributed to the normal mouse pancreas following systemic administration. One selectively accumulated in genetically modified mouse models of PDAC. The probe exhibited intracellular accumulation and enabled visualization of four levels of the structure, including the whole organ, resected tissue, individual cells, and subcellular organelles. In contrast to the small-molecule probes reported previously, it possesses an inherent affinity toward PDAC cells and thus does not require conjugation to any targeting agent. The fluorescent probe can thus promote new strategies not only for precision image-guided surgery, but also for PC detection, monitoring of therapeutic outcomes, and basic research.
Related content
Scientific Software in Light of the European Accessibility Act
Copy and paste, click and go, swipe right, drag and drop – these computer UI actions are so...
How to Marvin: UI Overview
Learn the logic behind Marvin's user interface from this episode of the How to Marvin video series.
How to Marvin: Chemical Naming
Learn how you can generate and convert chemical names from this episode of the How to Marvin video...
How to Marvin: Search Bar
Learn about the different uses of Marvin's search bar from this episode of the How to Marvin video...