Combinatorial Library Optimization Process In The European Lead Factory Project

poster · 6 years ago
by Tuomo Kalliokoski (Lead Discovery Center GmbH)
Instant JChem Consultancy

The European Lead Factory (ELF) is a 60 month, 196 million EUR project which has started on January 2013. There are 30 partners from both academia and the pharmaceutical industry. The aim of the project is to combine large combinatorial library with High-Throughput Screening (HTS)-facility to provide lead structures for drug discovery programs and tool compounds for target/mechanism validation (Figure 1). The 500,000-membered compound library (Joint European Compound Collection, JECC) consists of 300,000 compounds contributed the pharmaceutical companies Bayer, AstraZeneca, Lundbeck, Janssen, Merck, Sanofi and UCB (Figure 2). The additional 200,000 compounds are to be synthesized during the project by European academics and small- and medium-sized enterprises (SMEs).

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