A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P®) Mediated One-Pot Pyrazolone Synthesis

publication · 5 years ago
by Matthieu Desroses, Marie-Caroline Jacques-Cordonnier, Sabin Llona-Minguez, Sylvain Jacques, Tobias Koolmeister, Thomas Helleday, Martin Scobie (Karolinska Institute)
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This paper describes a facile, efficient, and clean synthesis of various pyrazolones by employing T3P® as a catalyst and performing the reaction under microwave irradiation. This two-step, one-pot reaction proceeded readily and tolerated a variety of functional groups. A wide range of pyrazolone derivatives were obtained in good to excellent yields.

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