A new water-soluble ligand for efficient copper-catalyzed Huisgen cycloaddition of aliphatic azides and alkynes

publication · 3 years ago
by Przemysław W. Szafranski, Patryk Kasza, Marek T. Cegła (Jagiellonian University Medical College)

Efficient procedures for the copper-catalyzed Huisgen cycloaddition reaction in aqueous media were developed using a novel water-soluble catalytic ligand, 2-{4-[(dimethylamino)methyl]-1,2,3-triazol-1-yl}cyclohexan-1-ol (AMTC). A series of aliphatic and aromatic substrates were tested and compared to the well-known tris(triazole)amine ligands (TBTA and THPTA). The effect of solvent composition was also investigated.

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