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Passive Permeability of Planar Lipid Bilayers to Organic Anions
The membrane permeability P of organic ions was reported to be governed by the structure of the...
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
DNA damage repair enzymes are promising targets in the development of new therapeutic agents for a...
Rapid Method Development in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical Analysis
A design-of-experiment (DoE) model was developed, able to describe the retention times of a mixture...
Minimalist Approach to Design of ComplexityEnriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents
Over the last decades, much effort has been devoted to the design of the “ideal” library for...
Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/ HLA-A2 interactions
The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an...
In-silico profiling of the biological activities of Amaryllidaceae alkaloids
Objectives The large number of publications about Amaryllidaceae alkaloids reflects the abundance...
Identification of Unknown Antiandrogenic Compounds in Surface Waters by Effect-Directed Analysis (EDA) Using a Parallel Fractionation Approach
Among all the nuclear-receptor mediated endocrine disruptive effects, antiandrogenicity is...
Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog
Sodium channel inhibitor drugs decrease pathological hyperactivity in various diseases including...
Aquatic toxicity of several textile dye formulations: Acute and chronic assays with Daphnia magna and Raphidocelis subcapitata
Dyes are widely used in various sectors and can be released into the environment where they persist...
Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus
Zika flavivirus infection during pregnancy appears to produce higher risk of microcephaly, and also...
Screening of Pesticide and Biocide Patterns As Risk Drivers in Sediments of Major European River Mouths: Ubiquitous or River Basin-Specific Contamination?
Pesticides and biocides (PaB) are ubiquitously present in aquatic ecosystems due to their...
Occurrence of emerging persistent and mobile organic contaminants in European water samples
The release of persistent and mobile organic chemicals (PMOCs) into the aquatic environment puts...