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Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation
A critical limitation of bioorthogonal click chemistry for in vivo applications has been its low...
Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products
Over-regulation of Heme oxygenase 1 (HO-1) has been recently identified in many types of human...
Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2þ/ calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain
Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC) that...
Identification of a selective inhibitor of human monocarboxylate transporter 4
The human monocarboxylate transporters (hMCTs/SLC16As) mediate the uptake of various...
PSMA-targeted contrast agents for intraoperative imaging of prostate cancer
Prostate-specific membrane antigen (PSMA) can serve as a molecular cell surface target for the...
Use of dual-filtering to create training sets leading to improved accuracy in quantitative structure-retention relationships modelling for hydrophilic interaction liquid chromatographic systems
The development of quantitative structure retention relationships (QSRR) having sufficient accuracy...
Designing High-Refractive Index Polymers Using Materials Informatics
A machine learning strategy is presented for the rapid discovery of new polymeric materials...
Inhibitory effects of arylcoumarin derivatives on Bacteroides fragilis D-lactate dehydrogenase
Bacteroides fragilis is an anaerobic bacterium naturally hosted in the human colon flora. B....
2‐Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction
Antimicrobial resistance (AMR) represents a hot topic in drug discovery. Besides the identification...
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors
A series of 31 N,N-disubstituted 2-amino-5-halomethyl-2-thiazolines was designed, synthesized, and...
Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite
Cytochrome b5 reductase (Cb5R) is a pleiotropic flavoprotein that catalyzes multiple one-electron...
Novel medium-throughput technique for investigating drug-cyclodextrin complexation by pH-metric titration using the partition coefficient method
The present study was aimed to develop a medium-throughput screening technique for investigation of...