Community-based approach to research on infectious diseases of the developing world and global health
Currently, infectious diseases of the developing world (e.g., malaria, tuberculosis) represent a global health challenge of the 21st century and require new approaches that would allow scientists to do research more effectively. As a result of the development of web-database technologies, recently a community-based approach to research on infectious diseases of the developing world and global health has emerged. The major components of effective scientific community include: (1) unifying goal, or focus on common therapeutic areas/diseases; (2) multiple research areas/expertise; (3) uniform database platform that allows effective data accumulation and management; (4) easy access and sharing of information; (5) potential for unlimited growth. The Collaborative Drug Discovery (CDD) database built by utilizing community-based web technologies currently provides a platform that allows scientists to archive, mine, and share research data with a focus on infectious diseases of the developing world. This new collaborative technology allows researchers to build up networks of technical experts around therapeutic or target areas thus facilitating discovery of new drug candidates. It allows scientists to speed up the research by sharing unpublished data providing new hope in the race to overcome drug resistance. An example illustrating how potential chemosensitizers to address chloroquine resistance could be identified by using the CDD database platform is presented..