High-Throughput Screening for Identification of Inhibitors of the Bacterial Phosphatase YopH

poster · 9 years ago
by Mikael Elofsson, Per Anders Enquist, Jonas Eriksson, Anders Öhman, Christin Grundström, Elisabeth Sauer-Eriksson, Uwe Sauer (Umeå University)
JChem Base JChem Web Services

Our main goal was to establish a biochemical platform from assay setup to data management in order to set new standards for the service offered by LCBU. As target we chose tyrosine phosphatase (YopH)[1] which is one of the virulence factors produced by the Gram-negative bacterium Yersinia pseudotuberculosis. The set-up was optimized for assays in 384w plates.

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