Novel steroid receptor modulators identified by high-throughput profiling with panel of reporter cell lines

poster · 8 years ago
by David Sedlák, Ctibor Škuta, Daniel Svozil, Petr Bartůněk (Institute of Molecular Genetics AS CR, CZ-Openscreen)

Steroid hormone receptors (SR) are evolutionary and functionally related transcription factors regulating a broad variety of physiological functions. SRs consist of two receptors for estrogens (ERα and ERβ), an androgen receptor (AR), a glucocorticoid receptor (GR), a mineralocorticoid receptor (MR) and a progesterone receptor (PR). The regulation of transcription by SRs is highly complex but it shows a common trait: the activity can be modulated by low molecular weight ligands, which makes them one of the most prominent drug target. In addition to their role in the hysiology of healthy organism, SRs have a role in pathophysiological processes including cancer, metabolic disorders, neurodegeneration or inflammation.

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