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Rapid Method Development in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical Analysis
A design-of-experiment (DoE) model was developed, able to describe the retention times of a mixture...
Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action
Recent efforts by both academic and pharmaceutical researchers have focused on the HIV-1 capsid...
Halogen bonding enhances activity in a series of dual 5-HT6/D2 ligands designed in a hybrid bioisostere generation/virtual screening protocol
A novel hybrid bioisostere generation/virtual screening method combined with narrowing of chemical...
Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction
This review focuses on the biological action of the compounds from the group of substituted...
Ranking docking poses by graph matching of protein–ligand interactions: lessons learned from the D3R Grand Challenge 2
A novel docking challenge has been set by the Drug Design Data Resource (D3R) in order to predict...
Toward More Drug Like Inhibitors of Trypanosome Alternative Oxidase
New tools are required to ensure the adequate control of the neglected tropical disease human...
The impact of chloride or bromide ions on the advanced oxidation of atrazine by combined electrolysis and ozonation
Advanced oxidation of atrazine (ATZ) via electrolysis and ozonation separately and in combination...
Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss
Hearing loss affects more than two-thirds of the elderly population, and more than 17% of all...
From Click Chemistry to Cross-Coupling: Designer Polymers from One Efficient Reaction
Palladium-catalyzed Suzuki−Miyaura cross-coupling was demonstrated to be a versatile reaction...
Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction
Medium-ring natural products exhibit diverse biological activities but such scaffolds are...
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect b-secretase inhibitors
Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid...
A novel cluster of C5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold
A new series (6) of C5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is...