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The impact of chloride or bromide ions on the advanced oxidation of atrazine by combined electrolysis and ozonation
Advanced oxidation of atrazine (ATZ) via electrolysis and ozonation separately and in combination...
Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss
Hearing loss affects more than two-thirds of the elderly population, and more than 17% of all...
From Click Chemistry to Cross-Coupling: Designer Polymers from One Efficient Reaction
Palladium-catalyzed Suzuki−Miyaura cross-coupling was demonstrated to be a versatile reaction...
Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction
Medium-ring natural products exhibit diverse biological activities but such scaffolds are...
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect b-secretase inhibitors
Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid...
A novel cluster of C5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold
A new series (6) of C5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is...
Economical and Simple Preparation of Oleyl Bromide from Commercially Available Olive Oil
The objective of this work was to get access to a cheap and easy to scale source of oleyl bromide....
Privileged substructures for anti-sickling activity via cheminformatic analysis
Sickle cell disease (SCD), an autosomal recessive genetic disorder, has been recognized by the...
A Ligand-Based Approach to the Discovery of Lead-Like Potassium Channel KV1.3 Inhibitors
Voltage-gated ion channels are key molecular targets for autoimmune diseases such as multiple...
Analysis of the Frequency and Diversity of 1,3-Dialkylimidazolium Ionic Liquids Appearing in the Literature
The hypothetical assertion that there are potentially millions of ionic liquids (ILs) can be...
Structure Property Relationships of Carboxylic Acid Isosteres
The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical...
Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake
Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements...