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Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction
This review focuses on the biological action of the compounds from the group of substituted...
Ranking docking poses by graph matching of protein–ligand interactions: lessons learned from the D3R Grand Challenge 2
A novel docking challenge has been set by the Drug Design Data Resource (D3R) in order to predict...
Toward More Drug Like Inhibitors of Trypanosome Alternative Oxidase
New tools are required to ensure the adequate control of the neglected tropical disease human...
The impact of chloride or bromide ions on the advanced oxidation of atrazine by combined electrolysis and ozonation
Advanced oxidation of atrazine (ATZ) via electrolysis and ozonation separately and in combination...
Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss
Hearing loss affects more than two-thirds of the elderly population, and more than 17% of all...
From Click Chemistry to Cross-Coupling: Designer Polymers from One Efficient Reaction
Palladium-catalyzed Suzuki−Miyaura cross-coupling was demonstrated to be a versatile reaction...
Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction
Medium-ring natural products exhibit diverse biological activities but such scaffolds are...
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect b-secretase inhibitors
Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid...
A novel cluster of C5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold
A new series (6) of C5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is...
Economical and Simple Preparation of Oleyl Bromide from Commercially Available Olive Oil
The objective of this work was to get access to a cheap and easy to scale source of oleyl bromide....
Privileged substructures for anti-sickling activity via cheminformatic analysis
Sickle cell disease (SCD), an autosomal recessive genetic disorder, has been recognized by the...
A Ligand-Based Approach to the Discovery of Lead-Like Potassium Channel KV1.3 Inhibitors
Voltage-gated ion channels are key molecular targets for autoimmune diseases such as multiple...