Key Properties in Drug Design | Predicting Lipophilicity, pKa and Solubility

Posted by
Chemaxon
on 30 08 2022

PhysChem properties are key descriptors in drug design

Lipophilicity, pKa and solubility are key descriptors in drug design. Their importance to both pharmacokinetic exposure (ADME) and pharmacodynamic response (effect on target and off-targets) have been thoroughly studied and described in the literature. Most drug discovery companies are measuring these properties in a high-throughput manner and drug designers are frequently predicting them prior to prioritizing compounds for synthesis

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