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Nuclear Receptors Database Including Negative Data (NR-DBIND): A Database Dedicated to Nuclear Receptors Binding Data Including Negative Data and Pharmacological Profile
Nuclear receptors (NRs) are transcription factors that regulate gene expression in various...
Synthesis, structural, spectroscopic and DFT study on a palladium(II)- N-heterocyclic carbene complex
A new palladium complex with N-heterocyclic carbene (NHC) and phosphine ligands was prepared and...
Combined Ligand- and Receptor-Based Virtual Screening Methodology to Identify Structurally Diverse Protein Tyrosine Phosphatase 1B Inhibitors
Protein tyrosine phosphatase 1B (PTP1B) is a potential drug target for diabetes and obesity....
Evaluation of commercially available styrene-co-maleic acid polymers for the extraction of membrane proteins from spinach chloroplast thylakoids
ABSTRACT: Solubilization of membrane proteins by poly(styrene-co-maleic acid) salts (pSMA-S) has...
N-haloacetyl phenothiazines and derivatives: Preparation, characterization and structure-activity relationship for antifungal activity
ABSTRACT: A serie of N-acetyl phenothiazines and related compounds was synthesized by means of the...
Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/ HLA-A2 interactions
The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an...
Anandamide targets aromatase: A breakthrough on human decidualization
In each menstrual cycle endometrial stromal cells (hESC) proliferate and differentiate into...
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier- Mediated Process
The weak base antipsychotic clozapine is the most effective medication for treating refractory...
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers
The phytochemical study of Euphorbia pedroi led to the isolation of a new tetracyclic triterpenoid...
Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology
This review discusses the current knowledge of the phytochemistry and in vitro and in vivo...
Prediction and Interpretable Visualization of Retrosynthetic Reactions using Graph Convolutional Networks
Recently, many research groups have been addressing data-driven approaches for (retro)synthetic...
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
Drugs frequently require interactions with multiple targets—via a process known as...