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Small Molecule Efflux Pump Inhibitors in Mycobacterium tuberculosis: A Rational Drug Design Perspective
Drug resistance in Mycobacterium tuberculosis (M. tuberculosis) complicates management of...
Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-b-lactams
Large, diverse compound libraries are an essential requisite in target-based drug development. In...
Synthesis by Click Reactions and Antiplasmodial Activity of Lupeol 1,2,3-Triazole Derivatives
Lupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity...
Integrated design and idea management platform for drug discovery
Drug discovery is an iterative process of rational hypothesis construction and validation through...
EDCs DataBank: 3D-Structure database of endocrine disrupting chemicals
Endocrine disrupting chemicals (EDCs) are a group of compounds that affect the endocrine system,...
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists
On the basis of the long-known prototypic pharmacophore 3-(1H-imidazol-4-yl)propylguanidine (SK&F...
A comparison of equilibrium and kinetic passive sampling for monitoring of aquatic organic contaminants in German rivers
The performances of an equilibrium and a kinetic passive sampler for monitoring a range of organic...
Neo-Chlorogenic Acid: Conformational and Molecular Analysis by Semi-Empirical Methods
This paper shows results regarding semiempiric results for neochlorogenic acid, from geometrical...
The flexible cytoplasmic loop 3 contributes to the substrate affinity of human monocarboxylate transporters
Human monocarboxylate transporters (hMCTs/SLC16As) mediate the transport of small molecular weight...
Chemical Intelligence That Makes Hidden Knowledge Effortlessly Reachable
The knowledge, that is being produced and stored in the forms of reports, patents and scientific...
Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses
Glycomics has become an increasingly important field of research since glycans play critical roles...
Tandem Mass Spectrometry and Ion Mobility Reveals Structural Insight into Eicosanoid Product Ion Formation
Ion mobility measurements of productions were used to characterize the collisional cross section...