Chemaxon blog
Filter by content type
High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds
Bone morphogenetic protein (BMP) signaling is critical in renal development and disease. In animal...
In Silico HCT116 Human Colon Cancer Cell-Based Models En Route to the Discovery of Lead-Like Anticancer Drugs
To discover new inhibitors against the human colon carcinoma HCT116 cell line, two quantitative...
Inhibitory effects of arylcoumarin derivatives on Bacteroides fragilis D-lactate dehydrogenase
Bacteroides fragilis is an anaerobic bacterium naturally hosted in the human colon flora. B....
Bitter and sweet tasting molecules: It's complicated
“Bitter” and “sweet” are frequently framed in opposition, both functionally and metaphorically, in...
2‐Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction
Antimicrobial resistance (AMR) represents a hot topic in drug discovery. Besides the identification...
Metagenomic discovery of a novel transaminase for valorization of monoaromatic compounds
The profitability of next-generation biorefineries is acutely contingent on the discovery and...
Organoarsenicals in poultry litter: Detection, fate, and toxicity
Arsenic contamination in groundwater has endangered the health and safety of millions of people...
A Computer-Driven Approach to Discover Natural Product Leads for Methicillin-Resistant Staphylococcus aureus Infection Therapy
The risk of methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing in both the...
Design Hub for early phase drug discovery
Drug discovery is an iterative process of hypothesis construction relying on observations and...
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors
A series of 31 N,N-disubstituted 2-amino-5-halomethyl-2-thiazolines was designed, synthesized, and...
Screening of Pesticide and Biocide Patterns As Risk Drivers in Sediments of Major European River Mouths: Ubiquitous or River Basin-Specific Contamination?
Pesticides and biocides (PaB) are ubiquitously present in aquatic ecosystems due to their...
Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite
Cytochrome b5 reductase (Cb5R) is a pleiotropic flavoprotein that catalyzes multiple one-electron...