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Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors
A series of 31 N,N-disubstituted 2-amino-5-halomethyl-2-thiazolines was designed, synthesized, and...
Screening of Pesticide and Biocide Patterns As Risk Drivers in Sediments of Major European River Mouths: Ubiquitous or River Basin-Specific Contamination?
Pesticides and biocides (PaB) are ubiquitously present in aquatic ecosystems due to their...
Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite
Cytochrome b5 reductase (Cb5R) is a pleiotropic flavoprotein that catalyzes multiple one-electron...
Site of metabolism prediction for oxidation reactions mediated by oxidoreductases based on chemical bond
MOTIVATION: The metabolites of exogenous and endogenous compounds play a pivotal role in the domain...
Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging
Molecular probes that selectively highlight pancreatic cancer (PC) tissue have the potential to...
Temperature-Dependent Estimation of Gibbs Energies Using an Updated Group-Contribution Method
Reaction-equilibrium constants determine the metabolite concentrations necessary to drive flux...
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation
Ethionamide (ETH) is one of the most widely used second-line chemotherapeutic drugs for the...
Novel medium-throughput technique for investigating drug-cyclodextrin complexation by pH-metric titration using the partition coefficient method
The present study was aimed to develop a medium-throughput screening technique for investigation of...
Characterization of the Penetration of the Blood–Brain Barrier by High-Performance Liquid Chromatography (HPLC) Using a Stationary Phase with an Immobilized Artificial Membrane
The biological activity of drugs on organisms is associated with the pharmacokinetic properties,...
Potential of marine natural products against drug-resistant bacterial infections
Natural products have been a rich source of compounds with structural and chemical diversity for...
Occurrence of emerging persistent and mobile organic contaminants in European water samples
The release of persistent and mobile organic chemicals (PMOCs) into the aquatic environment puts...
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2‑AminopyridineBased Scaffolds with a Fluorobenzene Linker
Inhibition of neuronal nitric oxide synthase (nNOS) is a promising therapeutic approach to treat...