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Evaluation of an Artificial Neural Network Retention Index Model for Chemical Structure Identification in Nontargeted Metabolomics
Liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS)...
Removal of polar organic micropollutants by pilot-scale reverse osmosis drinking water treatment
The robustness of reverse osmosis (RO) against polar organic micropollutants (MPs) was investigated...
Acemetacin–phosphatidylcholine interactions are determined by the drug ionization state
Gastrointestinal (GI) toxicity is a major drawback of the chronic use of nonsteroidal...
Antibacterial prenylated stilbenoids from peanut (Arachis hypogaea)
Stilbenoids are a class of secondary metabolites with a stilbene backbone that can be produced by...
Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation
A critical limitation of bioorthogonal click chemistry for in vivo applications has been its low...
Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
A series of 5-aryl-1-alkylimidazole derivatives was synthesized using the van Leusen multicomponent...
Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2þ/ calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain
Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC) that...
Identification of a selective inhibitor of human monocarboxylate transporter 4
The human monocarboxylate transporters (hMCTs/SLC16As) mediate the uptake of various...
PSMA-targeted contrast agents for intraoperative imaging of prostate cancer
Prostate-specific membrane antigen (PSMA) can serve as a molecular cell surface target for the...
Indolizine-Based Scaffolds as Efficient and Versatile Tools: Application to the Synthesis of Biotin-Tagged Antiangiogenic Drugs
We describe the design and optimization of polyfunctional scaffolds based on a fluorescent...
Rapid membrane permeabilization of Listeria monocytogenes and Escherichia coli induced by antibacterial prenylated phenolic compounds from legumes
Prenylated phenolics from the Fabaceae are promising lead compounds for new antibacterials. Pools...
Small Molecule Efflux Pump Inhibitors in Mycobacterium tuberculosis: A Rational Drug Design Perspective
Drug resistance in Mycobacterium tuberculosis (M. tuberculosis) complicates management of...