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A novel cluster of C5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold
A new series (6) of C5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is...
Analysis of the Frequency and Diversity of 1,3-Dialkylimidazolium Ionic Liquids Appearing in the Literature
The hypothetical assertion that there are potentially millions of ionic liquids (ILs) can be...
Structure Property Relationships of Carboxylic Acid Isosteres
The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical...
Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists
The oxoeicosanoid receptor 1 (OXER1) is a member of the G-protein coupled receptors (GPCR) family,...
Multicomponent crystals of nitrofurazone – when more is less
Multicomponent crystal formation of nitrofurazone, a conformationally flexible drug that is capable...
Functionalised bicyclic tetramates derived from cysteine as antibacterial agents
Routes to bicyclic tetramates derived from cysteine permitting ready incorporation of functionality...
Atom-by-atom tuning of the electrostatic potassiumchannel modulator dehydroabietic acid
Dehydroabietic acid (DHAA) is a naturally occurring component of pine resin that was recently shown...
Foodinformatics: Quantitative Structure-Property Relationship Modeling of Volatile Organic Compounds in Peppers
The aim of this work was the foodinformatic (chemoinformatic) modeling of volatile organic...
The Tetrazole Analogue of the Auxin Indole-3-acetic Acid Binds Preferentially to TIR1 and Not AFB5
Indole-3-acetic acid (auxin) is considered one of the cardinal hormones in plant growth and...
Minimalist Approach to Design of ComplexityEnriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents
Over the last decades, much effort has been devoted to the design of the “ideal” library for...
Internal Concentrations in Gammarids Reveal Increased Risk of Organic Micropollutants in Wastewater-Impacted Streams
Internal concentrations link external exposure to the potential effect, as they reflect what the...
Conjugates of methylene blue with y-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases
We studied the inhibitory activity of methylene blue (MB) γ-carbolines (gC) conjugates (MB-gCs)...