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Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action
Recent efforts by both academic and pharmaceutical researchers have focused on the HIV-1 capsid...
Halogen bonding enhances activity in a series of dual 5-HT6/D2 ligands designed in a hybrid bioisostere generation/virtual screening protocol
A novel hybrid bioisostere generation/virtual screening method combined with narrowing of chemical...
Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction
This review focuses on the biological action of the compounds from the group of substituted...
Toward More Drug Like Inhibitors of Trypanosome Alternative Oxidase
New tools are required to ensure the adequate control of the neglected tropical disease human...
The impact of chloride or bromide ions on the advanced oxidation of atrazine by combined electrolysis and ozonation
Advanced oxidation of atrazine (ATZ) via electrolysis and ozonation separately and in combination...
Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss
Hearing loss affects more than two-thirds of the elderly population, and more than 17% of all...
From Click Chemistry to Cross-Coupling: Designer Polymers from One Efficient Reaction
Palladium-catalyzed Suzuki−Miyaura cross-coupling was demonstrated to be a versatile reaction...
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect b-secretase inhibitors
Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid...
A novel cluster of C5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold
A new series (6) of C5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is...
A Ligand-Based Approach to the Discovery of Lead-Like Potassium Channel KV1.3 Inhibitors
Voltage-gated ion channels are key molecular targets for autoimmune diseases such as multiple...
Analysis of the Frequency and Diversity of 1,3-Dialkylimidazolium Ionic Liquids Appearing in the Literature
The hypothetical assertion that there are potentially millions of ionic liquids (ILs) can be...
Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists
The oxoeicosanoid receptor 1 (OXER1) is a member of the G-protein coupled receptors (GPCR) family,...